Fig. 2.

Processing pipeline. Method for constructing structural brain networks from T1 and DWI data. Cortical and sub-cortical nodes were defined by segmentation of the T1-weighted structural scan. Edges were determined by seeding streamlines from the cortical grey/white matter interface and performing tractography using the fibre orientation distribution obtained by spherical deconvolution of the measured diffusion signal. Edges were weighted by the mean FA along all streamlines passing between the corresponding pair of nodes, and the resulting network was represented by a connectivity matrix.