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. 2021 Feb 10;30:102582. doi: 10.1016/j.nicl.2021.102582

Table 1.

Participant information. Demographics are shown for each of the TBSS and network analysis groups. Two measures of socio-economic status are provided: social grade is defined by the National Readership Survey (www.nrs.co.uk) and is based on parental occupation (A = upper middle class, B = middle class, C1 = lower middle class, C2 = skilled working class, D = working class, E = casual worker or unemployed); the index of multiple deprivation is defined by the UK Government (www.gov.uk/government/statistics/english-indices-of-deprivation-2019) and is based on post code at birth. Controls are matched to cases for both measures of socio-economic status in both datasets. Perinatal clinical information, as well as scores from neonatal MRI assessment of basal ganglia and thalami (BGT), white matter (WM) and posterior limbs of the internal capsule (PLIC), are given for cases.

TBSS
Network Analysis
Cases (n = 33) Controls (n = 36) p Cases (n = 22) Controls (n = 32) p
Age, median (range) 6.9 (6.0–7.9) 7.0 (6.1–7.9) 0.5555 7.0 (6.0–7.8) 7.0 (6.1–7.8) 0.5428
Sex, male/female 18/15 19/17 0.8894 12/10 16/16 0.7526
Social Grade, median (range) C1 (A–E) B (A–D) 0.1568 C1 (A–D) B (A–D) 0.0924
Index of Multiple Deprivation, median (range) 7 (1–10) 7 (2–10) 0.5211 7 (1–10) 7 (2–10) 0.8174
FSIQ, median (range) 93 (62–115) 108 (75–137) <0.0001 98 (62–114) 108 (75–137) 0.0010
Perceptual Reasoning, median (range) 90 (67–123) 108 (84–145) <0.0001 91 (67–110) 108 (84–145) <0.0001
Processing Speed, median (range) 97 (68–136) 106 (68–141) 0.0787 98.5 (75–136) 106 (68–141) 0.1221
Verbal Comprehension, median (range) 98 (73–126) 109 (81–126) 0.0012 98 (73–126) 109 (81–126) 0.0114
Working Memory, median (range) 97 (62–116) 105.5 (77–135) 0.0076 94 (62–116) 105.5 (77–135) 0.0290



Neonatal MRI Assessment
BGT, median (range) 0 (0–2) 0 (0–1)
WM, median (range) 1 (0–3) 1 (0–3)
PLIC, median (range) 0 (0–2) 0 (0–1)



Perinatal Clinical Information
Mode of delivery, vaginal/instrumental/emergency caesarean in labour/emergency caesarean not in labour 11/8/10/4 8/6/7/1
Assisted ventilation at 10 min of age, yes/no 24/9 17/5
Cardiac compressions required, yes/no 13/20 8/14
Apgar score at 10 min of age, median (range) 6 (0–10) 5 (0–10)
Worst pH within 1 h of birth, median (range) 6.98 (6.70–7.25) 6.98 (6.77–7.25)
Worst base excess within 1 h of birth, median (range) −16.0 (−31.0 to −4.8) −16.1 (−31.0 to −4.8)
Grade of encephalopathy: moderate, n (%) 25 (75.8) 18 (81.8)
Grade of encephalopathy: severe, n (%) 8 (24.2) 4 (18.2)
aEEG abnormalities prior to TH: moderate, n (%) 30 (90.9) 20 (90.9)
aEEG abnormalities prior to TH: severe, n (%) 3 (9.1) 2 (9.1)