Table 2.
Comparison of fasting plasma concentrations of bile acids, FGF19 and C4 between bariatric subjects and non-bariatric subjects.
| Non-bariatric | Bariatric (all) | p valuea | BDL (%) | |
|---|---|---|---|---|
| n | 22 | 22 | ||
| Primary BA | 0.087 [0.052; 0.325] | 1.208 [0.108; 5.085] | 0.003 | |
| CA | 0.035 [0.025; 0.104] | 0.561 [0.043; 1.245] | 0.006 | 25.0 |
| CDCA | 0.054 [0.027; 0.201] | 0.588 [0.066; 3.855] | 0.003 | 15.9 |
| Secondary BA | 0.317 [0.195; 0.412] | 0.665 [0.317; 2.095] | 0.006 | |
| LCA* | 0.025 [0.025; 0.025] | 0.025 [0.025; 0.025] | 0.75 | 85.0 |
| DCA | 0.209 [0.120; 0.335] | 0.581 [0.213; 1.750] | 0.004 | 0.0 |
| UDCA | 0.050 [0.050; 0.050] | 0.050 [0.050; 0.157] | 0.017 | 70.5 |
| Taurine conjugated BA | 0.158 [0.150; 0.199] | 0.256 [0.154; 0.354] | 0.009 | |
| TCA | 0.050 [0.050; 0.050] | 0.050 [0.050; 0.050] | 0.60 | 77.3 |
| TCDCA | 0.031 [0.025; 0.066] | 0.087 [0.029; 0.137] | 0.005 | 29.5 |
| TLCA | 0.025 [0.025; 0.025] | 0.025 [0.025; 0.025] | – | 100 |
| TDCA | 0.025 [0.025; 0.035] | 0.031 [0.025; 0.092] | 0.011 | 43.2 |
| TUDCA | 0.025 [0.025; 0.025] | 0.025 [0.025; 0.025] | 0.32 | 97.7 |
| Glycine-conjugated BA | 0.584 [0.297; 0.838] | 1.546 [0.726; 2.544] | 0.001 | |
| GCA | 0.058 [0.049; 0.132] | 0.179 [0.073; 0.445] | 0.010 | 4.5 |
| GCDCA | 0.282 [0.122; 0.416] | 0.861 [0.376; 1.168] | 0.001 | 2.3 |
| GLCA | 0.025 [0.025; 0.025] | 0.025 [0.025; 0.034] | 0.173 | 75.0 |
| GDCA | 0.117 [0.056; 0.222] | 0.260 [0.136; 0.485] | 0.011 | 9.1 |
| GUDCA | 0.025 [0.025; 0.049] | 0.038 [0.025; 0.076] | 0.079 | 43.2 |
| Unconjugated BA | 0.416 [0.322; 0.684] | 2.022 [0.392; 8.046] | 0.004 | |
| Conjugated BA | 0.785 [0.452; 1.160] | 1.742 [0.876; 2.874] | 0.001 | |
| Total BA | 1.204 [0.906; 1.541] | 3.919 [2.410; 13.843] | 0.001 | |
| Ratios | ||||
| G:T | 3.07 [1.93; 4.03] | 5.84 [3.22; 8.25] | 0.010 | |
| Conjugated:unconjugated BA | 1.46 [1.03; 2.16] | 0.86 [0.26; 2.32] | 0.57 | |
| CA:DCA | 0.55 [0.33; 0.82] | 0.78 [0.45; 1.62] | 0.200 | |
| 12α:non-12α hydroxylated BA | 1.44 [1.04; 1.62] | 1.06 [0.76; 1.36] | 0.042 | |
| FGF19 | 74.85 [41.56; 126.74] | 131.19 [68.20; 181.23] | 0.039 | |
| C4 | 42.00 [29.78; 66.63] | 40.10 [22.03; 77.68] | 0.96 |
BA concentrations in µmol/L, FGF19 concentrations in pg/mL and C4 concentrations in nmol/L. Data are median [IQR].
BA bile acid, BDL below detection limit, G:T glycine-conjugated bile acids to taurine conjugated bile acids.
*n = 20 versus n = 20 because of four unintegrated peaks of LCA.
aData were compared with a related samples Wilcoxon rank Test between non-bariatric subjects and bariatric subjects.