Table 3.
Comparison of fasting plasma concentrations of bile acids, FGF19 and C4 between bariatric subjects with (RYGB-CC) or without (RYGB) prior cholecystectomy.
| RYGB-CC | RYGB | p valuea | BDL (%) | |
|---|---|---|---|---|
| n | 11 | 11 | ||
| Primary BA | 1.358 [0.130; 7.440] | 1.028 [0.084; 2.440] | 0.48 | |
| CA | 0.752 [0.042; 1.410] | 0.369 [0.043; 1.150] | 0.75 | 9.1 |
| CDCA | 0.715 [0.088; 6.030] | 0.516 [0.041; 1.290] | 0.52 | 9.1 |
| Secondary BA | 0.848 [0.293; 4.208] | 0.573 [0.325; 1.105] | 0.48 | |
| LCA* | 0.025 [0.025; 0.029] | 0.025 [0.025; 0.025] | 0.23 | 77.3 |
| DCA | 0.773 [0.208; 3.880] | 0.498 [0.250; 1.030] | 0.52 | 0.0 |
| UDCA | 0.068 [0.050; 0.236] | 0.050 [0.050; 0.050] | 0.171 | 59.1 |
| Taurine conjugated BA | 0.266 [0.163; 0.458] | 0.173 [0.150; 0.313] | 0.171 | |
| TCA | 0.050 [0.050; 0.050] | 0.050 [0.050; 0.050] | 1.00 | 77.3 |
| TCDCA | 0.088 [0.037; 0.253] | 0.038 [0.025; 0.132] | 0.24 | 22.7 |
| TLCA | 0.025 [0.025; 0.025] | 0.025 [0.025; 0.025] | – | 100 |
| TDCA | 0.032 [0.025; 0.107] | 0.025 [0.025; 0.078] | 0.24 | 36.4 |
| TUDCA | 0.025 [0.025; 0.025] | 0.025 [0.025; 0.025] | 0.75 | 95.5 |
| Glycine-conjugated BA | 1.662 [1.463; 3.188] | 0.809 [0.369; 1.873] | 0.034 | |
| GCA | 0.241 [0.154; 0.512] | 0.077 [0.041; 0.263] | 0.088 | 4.5 |
| GCDCA | 0.958 [0.786; 2.300] | 0.432 [0.195; 1.080] | 0.116 | |
| GLCA | 0.033 [0.025; 0.058] | 0.025 [0.025; 0.025] | 0.047 | 68.2 |
| GDCA | 0.391 [0.221; 0.739] | 0.195 [0.080; 0.456] | 0.116 | 9.1 |
| GUDCA | 0.039 [0.028; 0.161] | 0.034 [0.025; 0.072] | 0.193 | 27.3 |
| Unconjugated BA | 2.101 [0.375; 12.248] | 1.727 [0.397; 3.301] | 0.61 | |
| Conjugated BA | 2.177 [1.711; 3.549] | 0.959 [0.519; 2.186] | 0.047 | |
| Total BA | 5.256 [3.812; 13.964] | 2.783 [1.370; 5.982] | 0.065 | |
| Ratios | ||||
| G:T | 8.19 [5.71; 9.89] | 5.33 [2.46; 5.98] | 0.001 | |
| Conjugated:unconjugated BA | 1.08 [0.14; 6.20] | 0.81 [0.28; 2.32] | 0.65 | |
| CA:DCA | 0.88 [0.34; 1.84] | 0.71 [0.53; 1.26] | 0.85 | |
| 12α:non-12α hydroxylated BA | 1.00 [0.70; 1.51] | 1.14 [0.89; 1.31] | 0.40 | |
| FGF19 | 88.84 [64.79; 186.25] | 135.80 [79.96; 179.56] | 0.90 | |
| C4 | 75.70 [29.20; 99.00] | 27.20 [14.10; 56.60] | 0.047 |
BA concentrations in µmol/L, FGF19 concentrations in pg/mL, C4 concentrations in nmol/L. Data are median [IQR].
BA bile acid, BDL below detection limit, G:T glycine-conjugated bile acids to taurine conjugated bile acids.
*n = 9 with CC versus n = 11 without CC because of 2 unintegrated peaks of LCA.
aData were compared with a Mann–Whitney U Test between the bariatric subject with CC (n = 11) and the bariatric subjects without CC (n = 11).