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. 2021 Jan 15;40(8):1516–1530. doi: 10.1038/s41388-020-01627-y

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© The Author(s), under exclusive licence to Springer Nature Limited part of Springer Nature 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Representative tumour, MRI images (35 days), 3D-Micro-CT images (35 d), and H&E (35 d) of U251-Ctrl and U251-BATF2 group. Red dotted area highlights tumour area. Scale bars,100 μm. B The average intracranial tumour volume (n = 5, *p < 0.05, **p < 0.01, ***p < 0.001). C The average subcutaneous tumour volume of U251-Ctrl and U251-BATF2 (n = 5, *p < 0.05, **p < 0.01, ***p < 0.001). D The average subcutaneous tumour weight of U251-Ctrl and U251-BATF2 (n = 5, *p < 0.05, **p < 0.01, ***p < 0.001). E Representative tumour, MRI images, 3D-micro-CT images, and H&E images of U87-sh-NC, U87-sh-554 and U87-sh-1068 group. Red dotted area highlights tumour area. Scale bars,100 μm. F The average intracranial tumour volume (n = 5, *p < 0.05, **p < 0.01, ***p < 0.001). G The average tumour volume of U87-sh-NC, U87-sh-554 and U87-sh-1068 (n = 6, *p < 0.05, **p < 0.01, ***p < 0.001). H The average tumour weight of U87-sh-NC, U87-sh-554 and U87-sh-1068 (n = 6, *p < 0.05, **p < 0.01, ***p < 0.001).