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. 2020 Dec 21;6(3):339–353. doi: 10.1038/s41564-020-00846-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, Outline of the RAP–MS method to identify proteins bound to SARS-CoV-2 RNA and their crosslinked RNA sequences. b, Quantification of SARS-CoV-2 RNA-interacting proteins relative to RMRP-interacting proteins. The scatter plot of log₂-transformed TMT ratios from two biological replicates is shown. The grey dots represent all proteins detected with two or more unique peptides. c, Proteins enriched in SARS-CoV-2 RNA purifications (Supplementary Table 1). Left: core SARS-CoV-2 RNA interactome (adjusted P < 0.05). Left and right: expanded SARS-CoV-2 RNA interactome. Significantly enriched proteins are highlighted in teal; SARS-CoV-2-encoded proteins are highlighted in magenta. Adjusted P value: two-tailed moderated t-test.