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. 2020 Dec 21;6(3):339–353. doi: 10.1038/s41564-020-00846-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a, RT-qPCR measurements of intracellular SARS-CoV-2 RNA (RdRP gene) in infected Calu3, Huh7 and A549-ACE2 cells after inhibitor treatment. Inhibitors were used at indicated concentration (left to right). Calu3 cells were assayed 24 h post-infection, Huh7 and A549-ACE2 cells were assayed 48 h post-infection. Values are normalized to 18S rRNA measurements and compared to untreated or DMSO treated cells. b, Infectious viral titers in the supernatants of infected Calu3, Huh7 and A549-ACE2 cells after inhibitor treatment. Inhibitors were used at indicated concentration (left to right). Calu3 cells were assayed 24 h post-infection, Huh7 and A549-ACE2 cells were assayed 48 h post-infection. All values in a-b are mean ± s.d. (n = 3 independent infections) c-d, Cell viability assay in inhibitor-treated and untreated cells. Values are the mean ± s.d. (n = 3 independent treatments). P values determined in unpaired two-tailed t-test. ***P < 0.001; **P < 0.01; *P < 0.05; ns, not significant.