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. 2021 Jan 8;40(8):1409–1424. doi: 10.1038/s41388-020-01621-4

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© The Author(s) 2021, corrected publication 2021

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Fig. 8 — PFKFB3 inhibition led to the inactivation of the Akt/mTOR signaling pathway, induced apoptosis and autophagy, disrupted DNA Repair which consequently enhanced cell death and chemosensitivity.