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. 2021 Jan 25;6(3):354–365. doi: 10.1038/s41564-020-00840-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — Listed next to each metabolic step are the total relative abundance of all genomes capable of carrying out the step, and the number of genomes containing the capacity for that step. Arrow sizes are drawn proportional to the total relative abundance of genomes capable of carrying out the metabolic step.