Table 2: Top 15 signaling pathways identified.

The top 15 signaling pathways and their biological roles. The score given to each pathway is based on Correlation’s Engine statistical analysis.

Biogroup	Score	Role in the human body
Regulation of cell activation	100	Modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand [50]
Innate immune response	99	Defense responses mediated by germline encoded components that directly recognize components of potential pathogens [51]
Positive regulation of immune response	96	Activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus [52]
Regulation of lymphocyte activation	89	Any process that modulates the frequency, rate or extent of lymphocyte activation [53]
Inflammatory response	87	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages [16]
Leukocyte activation	85	A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor [54]
Lymphocyte activation	75	Change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor [55]
External side of plasma membrane	74	The side of the plasma membrane that is opposite to the side that faces the cytoplasm [56]
Immunoglobulin subtype	72	The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulphide bonds [57]
Vasculature development	72	The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. [58]
Activation of immune response	69	Any process that initiates an immune response [59]
Leukocyte migration	68	The movement of a leukocyte within or between different tissues and organs of the body [60]
Cell surface	68	The external part of the cell wall and/or plasma membrane [61]
Regulation of defense response	68	Any process that modulates the frequency, rate or extent of a defense response [62]
Blood vessel morphogenesis	64	The process in which the anatomical structures of blood vessels are generated and organized [63]