Table 5: The top upregulated genes.

The gene abbreviation is followed by a score which is provided by the BaseSpace correlation engine. The descriptive name of the gene is also mentioned. Corresponding role of the gene in our body is also listed.

	Gene	Score	Description	Role in the human body	Implicated in
					Inflammatory diseases	Drug delivery
1	CCL19	94	Chemokine (C-C motif) ligand 9	Chemokines are family of secreted proteins involved in immunoregulatory and inflammatory processes [64]	Yes [64]	Yes [65]
2	NOX2	83	NADPH oxidase 2	Primary component of the microbicidal oxidase system of phagocytosis [66]	Yes [67]	Yes [67]
3	FBLN1	82	Fibulin 1	It is a secreted glycoprotein that mediates platelet adhesion via binding fibrinogen [68]	Yes [69]	Yes [70]
4	HLA-DPA1	80	Major histocompatibility complex, class II, DP alpha 1	Plays a central role in the immune system by presenting peptides derived from extracellular proteins [71]	NA	NA
5	TMEM176B	76	Transmembrane protein 176B	Protein coding gene that plays a role in the maturation of dendritic cells [72]	NA	Yes [73]
6	LST1	75	Leukocyte specific transcript 1	Can inhibit the proliferation of lymphocytes [74]	Yes [75]	NA
7	PTHLH	75	Parathyroid hormone-like hormone	Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of mammary glands and teeth [76]	Yes [77]	NA
8	TDO2	71	Tryptophan 2,3-dioxygenase	Plays a role in catalyzing the first and rate-limiting step in major tryptophan metabolism [78]	Yes [79]	Yes [79]
9	CCL13	69	Chemokine (C-C motif) ligand 13	Cytokines are family of secreted proteins involved in immunoregulatory and inflammatory processes. Responsible for accumulation of leukocytes during inflammation [80]	Yes[81]	NA
10	CD79A	66	CD791 molecule, immunoglobulin-associated alpha	It is a B lymphocyte antigen receptor. It includes the antigen-specific component, surface immunoglobulin (Ig). It encodes the Ig-alpha protein of the B-cell antigen component [82]	NA	NA
11	CSF2RB	66	Colony stimulating factor 2 receptor	Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP) [83]	NA	NA
12	IGHG3	66	Immunoglobulin heavy constant gamma 3	Membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the differentiation of B lymphocytes into immunoglobulins-secreting plasma cells [84]	Yes [85]	NA
13	CLEC7A	65	C-type lectin domain family 7	It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked glucans from fungi and plants, and in a way plays a role in innate immune response [86]	NA	NA
14	CD27	63	CD27 molecule	Plays a role in regulating B-cell activation and immunoglobulin synthesis [87]	Yes [88]	Yes [89]
15	RNASE2	62	Ribonuclease, RNAse family 2	Protein has antimicrobial activity against viruses [90]	NA	NA
16	EMR1	62	Egf-like module containing, mucinlike, hormone receptor like 1	EMR1 expression in humans is restricted to eosinophils and is a specific marker for these cells [91]	Yes[41]	Yes[41]
17	FCER1G	62	Fc fragment of IgE	The high affinity IgE receptors is a key molecule involved in allergic reactions [92]	Yes [93]	NA
18	ZBP1	61	Z-DNA binding protein 1	It encodes a Z-DNA binding protein. Z-DNA formation is a dynamic process, largely controlled by the amount of supercoiling [94]	Yes [95]	NA
19	CEACAM21	60	Carcinoembryonic antigen-related cell adhesion molecule 21	Encoded proteins mediate cell adhesion and play a role in arrangement of tissue threedimensional structure, angiogenesis, apoptosis, metastasis and modulation of innate immune response [96]	NA	NA
20	ADAM19	59	ADAM metallopeptidase domain 19	It serves a s a marker for dendritic cell differentiation. They are also involved in normal physiological and pathological processes such as cell migration, cell adhesion, signal transduction etc. [97]	Yes [97]	Yes [97]
21	H2BC8	59	Histone cluster 1, H2bg	Plays a role in Cellular senescence, chromosome maintenance, cell cycle etc. [98]	NA	NA
22	SLAMF7	58	SLAM family member 7	It is a robust marker of normal plasma cells and malignant plasma cells in multiple myeloma [99]	NA	Yes [100]
23	SLFN5	57	schlafen family member 5	It is a member of the Schlafen family and may have a role in hematopoietic cell differentiation [101]	NA	NA
24	AIF1	57	Allograft inflammatory factor 1	Involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the antiinflammatory response to vessel wall trauma [102]	NA	NA
25	PECAM1	55	Platelet/endothelial cell adhesion molecule 1	Makes up a large portion of endothelial cell intercellular junctions and is involved in angiogenesis, vasculature development, leukocyte migration etc. [26]	Yes [28]	Yes [103]
26	HLA-DMB	54	Major histology complex, class II	Plays a central role in the peptide loading of MHC class II molecules by helping to release class II-associated invariant chain peptide molecule from the peptide binding site [104]	Yes [46]	Yes [46]
27	CYSLTR1	53	Cysteinyl leukotriene receptor 1	Activation of this receptor by LTD4 results in contradiction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung [105]	Yes [106]	Yes [106]
28	SELL	53	Selectin L	Plays an important role in leukocyte-endothelial cell interactions [27]	Yes [107]	Yes [107]
29	ARHGDIB	51	Rho GDP dissociation inhibitor beta	Involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization and secretion [108]	NA	NA
30	NCF4	51	Neutrophil cytosolic factor 4	Pi3 kinase signaling pathways are activated that are a part of cellular functions such as cell growth, proliferation, differentiation, survival etc. [109]	Yes [110]	NA