Table 6. The top downregulated genes.

The gene abbreviation is followed by a score which is provided by the BaseSpace correlation engine. The descriptive name of the gene is also mentioned. Corresponding role of the gene in our body is also listed.

	Gene	Score	Description	Role in the human body	Implicated in
					Inflammatory disease	Drug Delivery
1	SEC14L3	100	SEC-14 like 3	Essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins form the Golgi complex [111]	Yes [112]	NA
2	SLC6A13	92	Solute carrier family 6, member 13	Involved in signaling pathways such as, synaptic vesicle cycle and benzodiazepine pathway [113]	NA	NA
3	FYB2	92	Chromosome 1 open reading frame 168	Plays a role in T-cell receptor mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR simulation [114]	NA	NA
4	GSTA3	89	Glutathione S-transferase alpha 3	Involved in cellular defense against toxic, carcinogenic and pharmacologically active electrophilic compounds [115]	Yes [116]	NA
5	OSBPL6	85	Oxysterol binding protein-like 6	The gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors and the related pathways are synthesis of bile acids and bile salts and metabolism [117]	NA	NA
6	CCDC81	84	Coiled-coil domain containing 81	This gene is a member of the coiled coil domain structure family. Other functions are still unknown [118]	NA	NA
7	HHLA2	83	HERV-H LTR associating 2	Thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting proliferation of these cells [119]	NA	Yes [120]
8	ZBTB16	79	Zinc finger and BTB domain containing 16	This gene is involved in cell cycle progression, and interacts with a histone deacetylase [121]	NA	NA
9	SLC15A2	79	Solute family carrier 15, member 2	Responsible for the absorption of small peptides, as well as beta-lactam antibodies and other peptidelike drugs, from the tubular filtrate [122]	Yes [123]	NA
10	DNAH5	79	Dynein, axonemal, heavy chain 5	Functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke [124]	NA	NA
11	CSMD1	76	CUB and Sushi multiple domains 1	It is believed that the gene product of CSMD1 functions as Complement control protein [125]	NA	NA
12	CES1	76	Carboxylesterase 1	Responsible for hydrolysis of ester- and amide-bond containing drugs such as cocaine and heroin [126]	NA	NA
13	ARX	76	Aristaless related homebook	This gene is thought to be involved in Central Nervous System (CNS) development. Mutations in these genes cause epilepsy [127]	NA	NA
14	EGFL6	74	EGF-like-domain, multiple 6	Members of this superfamily (Epidermal Growth Factor family) are often involved in the regulation of cell cycle, proliferation and development processes [128]	NA	Yes [129]
15	KLHL32	73	Kelch-like 32	No reported function for this gene so far	NA	NA
16	TTC6	72	Tetratricopeptide repeat domain 6	Has shared roles in cilia formation and function [130]	NA	NA
17	ERICH5	72	Chromosome 8 open reading frame 47	Encodes a ubiquitously expressed protein of unknown function. It co-localizes at the base of primary cilium in human retinal pigment epithelial cells [131]	NA	NA
18	ARG2	71	Arginase, type II	They are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides and xenobiotics [132]	Yes [133]	NA
19	FMO5	70	Flavin containing monooxygenase 5	Flavin-containing monooxygenases are NAPDH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides and xenobiotics [134]	Yes [135]	NA
20	SLC23A1	69	Solute carrier family 23, member 1	The encoded protein is active in bulk vitamin C transport involving epithelial surfaces [136]	Yes [137]	NA
21	VEPH1	69	Ventricular zone expressed PH domain homolog 1	Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling [138]	NA	NA
22	NELL2	67	NEL-like 2 (chicken)	Plays a role in cell growth and differentiation as well as in oncogenesis [139]	NA	NA
23	MUC15	67	Mucin 15, cell surface associated	May play a role in the cell adhesion to the extracellular matrix [140]	Yes [141]	Yes [142]
24	PKIB	67	Protein kinase inhibitor beta	Study suggests that this protein may interact with the catalytic subunit of cAMP-dependent protein kinase and act as a competitive inhibitor [143]	NA	NA
25	FOXP2	66	Forkhead box P2	The product of this gene is thought to be required for proper development of speech and language regions of the brain during embryogenesis [144]	NA	Yes [144]
26	DLG2	66	Discs, large homolog	The encoded protein may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels and associated signaling proteins [145]	NA	NA
27	ADRB1	64	Adrenoceptor beta 1	Mediates the physiological effects of hormone epinephrine and the neurotransmitter norepinephrine [146]	NA	NA
28	PER1	63	Period homolog 1	Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6 [147]	Yes [148]	NA
29	ALDH3B1	63	Aldehyde dehydrogenase 3 family	Plays a major role in the detoxification of the aldehydes generated by alcohol metabolism and lipid peroxidation [149]	NA	NA
30	ERBB4	63	V-erb-a erythroblastic leukemia viral oncogene homolog 4	The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses [150]	Yes [150]	Yes [151]