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Pharmacokinetic parameters of free R848 and R848-TSLs injected i.v. in FVB mice. Cmax: maximum plasma concentration. t1/2: half-life. AUC0−∞: area under the curve. Vd: volume of distribution Cl: clearance.
| Cmax (μg/ml) | t1/2 (h) | AUC0−∞ (μg/ml*h) | Vd (mL) | Cl (mL/h) | |
|---|---|---|---|---|---|
| Free R848 | 2.61 ± 0.21 | 0.20 ± 0.05 | 0.63 ± 0.10 | 55.04 ± 6.39 | 195.06 ± 33.41 |
| R848-TSLs | 23.62 ± 1.13 | 0.53 ± 0.03 | 13.12 ± 0.67 | 7.07 ± 0.59 | 9.17 ± 0.48 |
