Table 2.
Univariate Cox regression analyses of renal survival in patients with IgAN
| Risk factor | Univariate | ||
|---|---|---|---|
| HR | 95% CI | P-value | |
| Age, years | 1.00 | 0.96–1.04 | 0.962 |
| Male | 1.41 | 0.66–3.00 | 0.376 |
| MAP, mmHg | 1.02 | 0.99–1.05 | 0.128 |
| WBC, × 109/L | 0.98 | 0.83–1.16 | 0.806 |
| Lymphocytes, × 109/L | 0.57 | 0.28–1.19 | 0.134 |
| Platelets, × 109/L | 1.00 | 0.99–1.01 | 0.471 |
| PLR > 137 | 3.10 | 1.44–6.64 | 0.004 |
| Hemoglobin, g/L | 0.97 | 0.95–0.99 | 0.001 |
| Serum albumin, g/l | 0.92 | 0.88–0.97 | 0.001 |
| Scr, μmol/L | 1.04 | 1.03–1.05 | < 0.001 |
| UA, μmol/L | 1.01 | 1.00–1.01 | < 0.001 |
| eGFR, ml/min/1.73 m2 | 0.92 | 0.90–0.95 | < 0.001 |
| Proteinuria, g/24 h | 1.38 | 1.16–1.63 | < 0.001 |
| Use of RAAS blockade | 0.59 | 0.27–1.30 | 0.190 |
| Use of IS | 0.23 | 0.11–0.51 | < 0.001 |
IgAN Immunoglobulin A nephropathy, HRs hazard ratios, CIs confidence intervals, PLR platelet-to-lymphocyte ratio, MAP mean arterial pressure, WBC white blood cell count, Scr serum creatinine, UA uric acid, eGFR estimated glomerular filtration rate, RAAS rein-angiotensin-aldosterone-system, IS immune suppression