Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 17;44(1):167–177. doi: 10.1007/s13402-020-00559-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — Raloxifene suppresses IL-6 secretion and IL-6-induced STAT3 phosphorylation in L3.6pl pancreatic cancer cells. ELISA showing that IL-6 concentrations are reduced after 24 hours of raloxifene treatment at different concentrations (a) (* p < 0.05). Representative Western blots showing that raloxifene inhibits IL-6-induced STAT3 phosphorylation in L3.6pl cells in a dose- and time-dependent manner (b and c, respectively). DARTS assay showing protein-ligand interaction between raloxifene and gp130. SC144 is a known gp130 inhibitor and was used as a positive control. The affinity of raloxifene to gp130 was similar to that of SC144 at a pronase concentration of 1:10,000 (d)