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. 2020 Sep 30;70(3):803–815. doi: 10.1007/s00262-020-02727-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Transcriptome analyses of differentially expressed genes in tumor-infiltrating CD33⁺ myeloid cells in CRC patients with early and advanced stage. We divided the patients into two groups based on disease stage; early stage (stages I and II, n = 8) and advanced stage (stages III and IV, n = 5), to compare their transcriptomic data. Volcano plot shows overall differentially regulated genes in patients with advanced stage compared to patients with early stage; red dots represent upregulated, green dots represent downregulated and gray dots represent genes, which remained unchanged with P values as a function of fold change and indicate the vertical dotted line to delimit > twofold change and P < 0.05 cutoffs (a). Bar plot shows functional annotations for the genes that were significantly upregulated or downregulated in CD33⁺ myeloid cells from advanced vs. early stages (b). Heatmaps show the Z-scores for various up- or downregulated genes and associated pathways in advanced vs. early stages (c)