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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Environ Toxicol Chem. 2020 Dec 7;40(3):606–630. doi: 10.1002/etc.4890

FIGURE 2:

FIGURE 2:

Example of proteins that are known to influence per- and polyfluoroalkyl substance toxicokinetics through binding (which affects tissue distribution and accumulation) and facilitation of membrane transport (which affects clearance and reabsorption). Illustrated for kidney and blood. L-FABP = liver fatty acid binding protein; Oat1 = organic anion transporting 1; Oatp1a1 = organic anion transporting polypeptide 1a1; Ost = organic solute transporter.