TABLE 1:
Per- and polyfluoroalkyl substances serum half-life estimates in rat, mouse, monkey, and humans
| PFBS (C4) | PFHxS (C6) | PFOS (C8) | PFBA (C4) | PFHxA (C6) | PFHpA (C7) | PFOA (C8) | PFNA (C9) | PFDA (C10) | F-53B | GenX | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| F | M | F | M | F | M | F | M | F | M | F | M | F | M | F | M | F | M | F | M | F | M | |
| Rat | 0.6–4.0 h | 2.1–4.5 h | 1.8 d | 6.8 d | 62–71d | 38–41d | 1.0–1.8 h | 6–9 h | 0.4–0.6 h | 1.0–1.7 h | 1.2 h | 2.4 h | 2–4 h | 4–6 d | 1.4–6.4 d | 31–55 d | 59–75 d | 40–80 d | 8 h | 3 h | ||
| Mouse | 4.5 h | 5.8 h | 25–2 d | 28–3 d | 31–3 d | 36–4 d | 3 h | 12 h | ~1.2 h | ~1.6 h | 16 d | 22 d | 26–6 d | 34–6 d | 18 h | 20 h | ||||||
| Cynomolgus Monkey | 3.5 d | 4.0 d | 87 d | 141 d | 110 d | 132 d | 1.7 d | 2.4 h | 5.3 h | 30 d | 21 d | |||||||||||
| Human | 28 d | 5.3–8.5 yr | 3.4–5.0 yr | 3 d | 32 d | 1.2–2.5 yr | 2.1–3.8 yr | 2.5–4.3 yr | 15.3 yr | |||||||||||||
GenX = hexafluoropropylene oxide dimer acid; PFBA = perfluorobutanoic acid; PFBS = perfluorobutanesulfonic acid; PFDA = perfluorodecanoic acid; PFHpA = perfluoroheptanoic acid; PFHxA = perfluorohexanoic acid; PFHxS = perfluorohexane sulfonate; PFNA = perfluorononanoic acid; PFOA = perfluorooctanoic acid; PFOS = perfluorooctane sulfonate.