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. Author manuscript; available in PMC: 2021 Jul 28.
Published in final edited form as: Nat Immunol. 2021 Jan 28;22(3):312–321. doi: 10.1038/s41590-020-00859-0

Figure 1: IRGM1 deficiency induces type I interferonopathy.

Figure 1:

a, Expression of interferon-stimulated genes (ISG) Ifit1 and Mx2 in lungs, spleen and bone marrow of wild type, Ifnar−/−, Irgm1−/− and Irgm1−/−Ifnar−/− animals (n=4/genotype). b, Representative H&E-stained sections of lungs, salivary glands (submandibular), lacrimal glands, and pancreas from indicated genotypes (n = 2-7/genotype) (scale bars, 100 μm, except pancreas [1000 μm]). c, Autoantibodies against indicated antigens, measured in serum of animals (n=3-4 mice/genotype). d, Cytokines and chemokines measured in serum (n=6 [Irgm1+/+, Ifnar−/−]; n=9 [Irgm1−/−]; n=10 [Irgm1−/−Ifnar−/−]). Data are mean +/− s.e.m. #P = 0.1, *P < 0.05, **P < 0.01, and ****P < 0.0001 (one-way ANOVA with Tukey’s adjustment).