Skip to main content
. Author manuscript; available in PMC: 2021 Jul 28.
Published in final edited form as: Nat Immunol. 2021 Jan 28;22(3):312–321. doi: 10.1038/s41590-020-00859-0

Figure 5: Tissue-selective involvement of cGAS/STING in autoimmune pathology of Irgm1-null mice.

Figure 5:

a,c, Representative H&E sections of lungs, salivary glands (submandibular), lacrimal glands, and pancreas from indicated genotypes (n=3-6/genotype) (scale bars, 100 μm, except pancreas [1000 μm]). b,d, Autoantibodies against indicated antigens, measured in serum of animals (n=3-4 mice/genotype). e, Cytokine levels in serum of animals (n=5 [Mb21d1−/−, Irgm1−/−Tmem173−/−]; n=6 [Irgm1+/+, Tmem173−/−, Irgm1−/−Mb21d1−/−]; n=8 [Irgm1−/−]). Data are mean +/− s.e.m. #P = 0.08, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 (one-way ANOVA with Tukey’s adjustment).