Skip to main content
. Author manuscript; available in PMC: 2021 Jul 28.
Published in final edited form as: Nat Immunol. 2021 Jan 28;22(3):312–321. doi: 10.1038/s41590-020-00859-0

Extended Data Fig. 1. Role for type I IFN in disease phenotypes of Irgm1−/− mouse.

Extended Data Fig. 1

a, Expression of interferon-stimulated genes in bronchoalveolar lavage (BAL) cells, bone marrow cells, and spleen of wild type and Irgm1−/− animals (n=3/genotype). b, Autoantibodies against full array of 124 antigens, measured in serum of animals (n=3-4 mice/genotype; each column is an independent mouse). c, Total count of bone marrow cells in wild type (n=8), Irgm1−/−(n=8), and Irgm1−/−Ifnar−/− (n=9) mice. d, Total leukocyte count (WBC), lymphocyte count, platelet count, hemoglobin concentration, and hematocrit in peripheral blood of wild-type (n=5), Ifnar−/− (n=3), Irgm1−/−(n=8), and Irgm1−/−Ifnar−/− (n=6) mice. Data are mean +/− s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001. Two-tailed unpaired t-test (a, d) and one-way ANOVA with Tukey’s adjustment (c).