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. Author manuscript; available in PMC: 2021 Aug 11.
Published in final edited form as: Nat Immunol. 2021 Feb 11;22(3):370–380. doi: 10.1038/s41590-021-00868-7

Extended Data Figure 6. Transcriptome analysis of control and Bach2 gRNA transduced P14 cells.

Extended Data Figure 6

a, Violin plots illustrating the mRNA amounts of differentially expressed genes between control (iris blue) and Bach2 gRNA (purple) transduced P14 cells on day 7 p.i.. Each dot represents one cell. b, Correlation between WT GP33 tetramer+ stem-like CD8+ T cells and control stem-like P14 CD8+ T cells (left) or between Bach2 KO GP33 tetramer+ stem-like CD8+ T cells and Bach2 gRNA stem-like P14 CD8+ T cells (right). 3 independent samples per condition. c, GSEA of RNA-Seq data from WT and Bach2 KO GP33 tetramer+ stem-like CD8+ T cells shows the enrichment of gene sets containing genes upregulated (left) or downregulated (right) in Bach2 gRNA transduced stem-like P14 cells relative to control stem-like P14 cells. d, Significantly enriched pathways in Fig. 6h determined by GSEA.