Table 2.

Studies investigating the association between cardiovascular risk factors, dementia and AD.

Study	Study design	Main results
Alzheimer's disease
Petrovitch et al. (2000)	Longitudinal cohort study	Elevated blood pressure in midlife associated with the development of neuritic plaques and neurofibrillary tangles in AD
Khachaturian et al. (2006)	Population-based cohort study	Use of antihypertensive drugs associated with a lower incidence of AD
Dementia
Guo et al. (1999)	Community-based cohort study	Use of antihypertensive drugs associated with a decreased risk for dementia
van Dijk et al. (2004)	Community-based cohort study	Hypertension associated with severe white matter lesions in non-demented individuals
Peila et al. (2006)	Population-based cohort study	Use of antihypertensive drugs associated with a reduced risk for dementia and cognitive decline in men