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. 2020 Oct 29;44(1):205–218. doi: 10.1007/s13402-020-00562-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — FGFRis decrease the proliferation of BC cells. (a) Proliferation of MCF-7, MDA- MB-231(SA) and MFM223 cells studied by measuring cell confluence using the IncuCyte ZOOM real-time imaging platform. One day after seeding, cells were treated with TKI258, BGJ398 or AZD4547 at the indicated concentrations and monitored up to 70 h. Confluence (%, mean ± SD, n = 8) was normalized to the corresponding value at 0 h (start of imaging). Statistical significances were analyzed for the area under the curve (AUC) over time and are shown compared to the control group (* p < 0.05, ** p < 0.01, *** p < 0.001). (b) Cells were treated as described above and viability was determined at the 70 h point using alamarBlue reagent. The columns represent the relative cell viabilities after 70 h FGFRi treatment compared to the control in each cell line (%, mean ± SD, n = 4–10). Statistical significances were determined using one-way ANOVA and adjusted for multiple comparison using Dunnett’s test, with the control group as reference. (* p < 0.05, ** p < 0.01, *** p < 0.001)