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. 2021 Feb 25;11:4615. doi: 10.1038/s41598-021-84222-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Proposed molecular model. In TNB breast cancer cell lines, overexpression of V1G1 affects cell migration in vitro by modulating EGFR stability and signaling that control activation of RAC1 and vinculin assembly. Similarly, overexpression of RAB7 affects EGFR degradation but also positioning of V-ATPase on endocytic organelles through RILP. In addition, overexpression of V1G1 reduces activation of MMPs that degrade extracellular matrix favoring cell migration in vivo. ECM extra-cellular matrix, EE early endosome, MVB multivesicular bodies, LE late endosome, LYS lysosome. Created with Biorender.com.