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Schematic of the proposed mechanism of lnc-CTSLP4 in GC progression
Lnc-CTSLP4, as a regulator with decreased levels in GC, binds to Hsp90α and recruits the E3 ubiquitin ligase ZFP91, which can block the interaction of Hsp90α with HNRNPAB and decreases the stability of HNRNPAB, subsequently promotes its degradation, thus reducing the transcriptional activation of Snail and inhibiting Snail-mediated EMT.
