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. 2021 Feb 25;11:4728. doi: 10.1038/s41598-021-83928-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Impact of oesophageal reflux disease and prior PPI-treatment on PVI safety outcome. (A) PVI-associated mediastinal oedema were significantly more frequently detected in patients with pre-existing erosive oesophageal reflux disease compared to non-reflux patients (p = 0.041). Shown is the number of patients with or without mediastinal oedema after PVI. (B) Patients with constant PPI medication prior to PVI significantly suffered less frequently from erosive oesophageal reflux disease, assessed directly prior to PVI by EDG, compared to patients without prior constant PPI intake (p = 0.049). Shown is the number of patients with or without erosive oesophageal reflux prior to PVI. (C) In patients with constant PPI-treatment prior to PVI, PVI-associated mediastinal oedema were significantly less frequently observed by post-interventional endosonography (p = 0.036). Shown is the number of patients with or without mediastinal oedema after PVI. EGD, oesophagogastroduodenoscopy; PPI, proton pump inhibitor; PVI, pulmonary vein isolation.