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. 2021 Feb 25;11:4678. doi: 10.1038/s41598-021-83851-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Several differentially methylated regions (DMRs) are found in the genomes of App^NL-F and App^NL-G-F mice when compared to WT. (A) A Venn diagram shows the number of unique and shared DMRs in each pair-wise comparison. (B) Violin plots demonstrate distribution of methylation differences among the DMRs in each genotype compared to WT controls. (C) Percentage of DMRs overlapping each genetic feature is shown. DMRs overlapping more than one feature are included in the counts for each overlapping feature. Proportions of hypo- and hypermethylated DMRs are shown on each bar. Groups with significant deviation from 50:50 split between hypo- and hypermethylated DMRs are marked with asterisk (*p < 0.05, **p < 0.005, and ***p < 0.0005). App^NL-G-F mice: n = 5; App^NL-F mice: n = 5; and WT mice: n = 4.