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. 2021 Feb 25;11:4678. doi: 10.1038/s41598-021-83851-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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DMR_394 contains a putative hippocampal gene regulatory element conserved in mouse and human. (A) The epigenetic landscape at DMR_394 is shown in adult mouse hippocampus tissue. Enhancer states are shown on top. All transcription start site (TSS) states are marked red, all enhancer chromatin states are colored yellow and all transcription-related chromatin states are shaded green. Open Regulatory Annotation (OReg Anno) Database elements are marked blue (regulatory regions) and orange (transcription factor binding site), with the name of the transcription factor believed to bind each element shown next to them. CTCF ChIP-seq fold-enrichment and significant peaks are shown in gray pileup and gray bar, respectively. (B) The epigenetic landscape at the human-equivalent of DMR_394 is shown. Chromatin state and OReg Anno colors match those described in panel A.