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. 2021 Feb 25;11:4709. doi: 10.1038/s41598-021-84180-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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AEA and AA protects flies from starvation stress and inhibits lipid metabolism. (A–E) Following two days of cannabinoid treatment, the percentage of the surviving flies was quantified to assess the resistance to starvation. Pre-treatment with 0.1 mg/ml AEA (A), 0.1 mg/ml AA (C), and 0.5 mM CP55940 (E) significantly enhanced the starvation resistance, while no effect was detected with 0.1 mg/ml 2-AG (B) and 1 mg/ml CBD (D) (n = 9–14 vials/group). (F) Quantification of the triacylglycerol (TAG) levels in the flies revealed a significant increase with 0.1 mg/ml AEA or 0.1 mg/ml AA pre-treatment following 18 h starvation as compared to the control group (n = 7–10 vials/group). Both one-sample t test and Log-rank (Mantel-Cox) test were used to determine the significant differences. *p < 0.05 and ***p < 0.001.