Table 4.
Hazard ratios for incident T2DM per 1 standard deviation decrease in mtDNA-CN and according to median, tertiles and quartiles of mtDNA-CN in study subjects.
| Dependent variable: Time to incident T2DM | Univariate | Adjusteda | ||
|---|---|---|---|---|
| HRb (p value) | 95% CI | HRb (p value) | 95% CI | |
| MtDNA-CN (decrease, standardised)c | 1.25 (0.004) | 1.07; 1.45 | 1.20 (0.02) | 1.02; 1.40 |
| MtDNA-CN mediand (low vs. high) | 1.45 (0.015) | 1.07; 1.94 | 1.43 (0.02) | 1.05; 1.95 |
| MtDNA-CN tertilee | ||||
| Low | 1.54 (0.02) | 1.06; 2.23 | 1.50 (0.04) | 1.02; 2.22 |
| Medium | 1.50 (0.03) | 1.03; 2.18 | 1.48 (0.048) | 1.00; 2.19 |
| High (ref) | 1 | 1 | ||
| MtDNA-CN quartilef | ||||
| Low | 1.88 (0.006) | 1.20; 2.93 | 1.78 (0.02) | 1.11; 2.83 |
| Med low | 1.79 (0.01) | 1.15; 2.80 | 1.75 (0.02) | 1.10; 2.79 |
| Med high | 1.56 (0.06) | 0.98; 2.46 | 1.45 (0.13) | 0.90; 2.35 |
| High (ref) | 1 | 1 | ||
aAdjusted for age, BMI, smoking, education and physical activity.
bHazard ratio for risk of incident T2DM.
cMtDNA has been reversed and standardized (HR for a one standard deviation decrease in mtDNA).
dLow mtDNA = 32.4–116, high mtDNA = 117–340.
eLow mtDNA = 32.4–105, medium mtDNA = 106–127, high mtDNA = 128–340.
fLow mtDNA = 32.4–99, medium low mtDNA = 100–116, medium high mtDNA = 117–134, high mtDNA = 135–340.
Prevalent cancer and prevalent T2DM were excluded. MtDNA-CN, Mitochondrial DNA copy number.
T2DM = type 2 diabetes mellitus; HR = hazard ratio; CI = confidence interval.