Table 1.

Different cell phenotypes densities according tumor compartments (epithelial, stoma and epithelial-stroma compartment) in malignant pleural mesothelioma patients (N = 12).

Phenotype	Median cell densities by tumor compartment (cells/mm2)
	Epithelial	Stroma	P*	Epithelial-Stroma
panCK +	2312.10	0.00	–	1471.03
panCK + PD-L1 +	661.54	0.00	–	421.22
panCK + KI67 +	294.19	0.00	–	143.00
panCK + KI67 + PD-L1 +	13.24	0.00	–	9.03
CD3 +	292.94	511.67	0.014	428.19
CD3 + PD-L1 +	45.12	11.42	0.003	38.55
CD3 + PD-1 +	15.34	32.94	0.114	26.69
CD3 + PD-1 + PD-L1 +	2.52	0.93	0.178	2.41
CD3 + KI67 +	17.22	30.75	0.143	19.05
CD3 + KI67 + PD-L1 +	6.45	3.37	0.551	5.17
CD3 + KI67 + PD-1 +	1.31	2.87	0.128	2.08
CD3 + KI67 + PD-1 + PD-L1 +	0.61	0.54	0.799	0.75
CD3 + Foxp3 + CD8 −	3.88	7.09	0.114	4.91
CD3 + Foxp3 + CD8 − PD-L1 +	0.72	0.00	< 0.001	0.39
CD3 + Foxp3 + CD8 − PD-1 +	0.88	0.65	1.000	1.00
CD3 + CD8 +	32.57	97.18	0.002	57.67
CD3 + CD8 + PD-L1 +	9.98	5.35	0.128	7.67
CD3 + CD8 + PD-1 +	4.45	7.97	0.219	7.80
CD3 + CD8 + PD-1 + PD-L1 +	1.12	0.26	0.321	1.13
CD3 + CD8 + KI67 +	2.92	9.47	0.045	5.89
CD3 + CD8 + KI67 + PD-L1 +	1.29	1.77	0.443	1.74
CD3 + CD8 + KI67 + PD-1 +	0.38	0.78	0.266	0.57
CD68 +	176.75	110.96	0.843	143.89
CD68 + KI67 +	13.10	6.91	0.347	9.75
CD68 + KI67 + PD-L1 +	3.58	0.57	0.114	2.54
CD68 + PD-L1 +	17.63	4.08	0.045	15.68

*P, comparison between tumor-epithelial and tumor-stroma compartment.