Table 1.

Metadata for Canada and UK cohorts.

Time series Samples	Country	Sex	Corneometer	Age	Menopausal status	Smoking status
1200 samples of 62 subjects	Canada	Female	[2.4–57.2] Median ~ 24.46 Mean ~ 24.36 Std ~ 8.87	[21–65] Median ~ 56.0 Mean ~ 52.7 Std ~ 11.36	324 samples of 18 subjects in pre-menopause 876 of 44 subjects in post-menopausal	286 samples of 19 smokers 914 samples of 43 non-smokers
278 samples of 102 subjects	UK	Female	[8.1–78.4] Median ~ 27.3 Mean ~ 31.70 Std ~ 12.42	[19–55] Median ~ 39.5 Mean ~ 38.74 Std ~ 9.09	–	–

See Supplementary Figure 1 for more details on the distributions of corneometer, age and samples per subjects. Also see Methods and Supplementary Notes for more detail on the sample collection.