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. 2021 Feb 25;11:4548. doi: 10.1038/s41598-021-84007-0

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Summary of conserved DRACHs among all HA subtypes of IAVs. From the centre, the HA cladding system is represented by a maximum-likelihood tree contain representing sequences of each subtype. The numbers of conserved DRACH motifs to each HA subtype that located on either vRNA or mRNA are indicated. The highly susceptible species affecting each subtype are indicated.