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. 2021 Feb 25;11:4691. doi: 10.1038/s41598-021-83913-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Kaplan–Meier curves demonstrating improvements in OS or DFS in TCGA TNBC patients with high quantities of CD8 T cells or CD4 memory activated T cells in their tumor sample, respectively. (a) TCGA TNBC patients with a higher proportion of CD8 T cells in their tumor have a better OS (p = 0.013, FDR = 0.24, log rank test) (survival rates high vs. low, 5 year: 96.4% and 71.9%, 10 year: 96.4% and 53.9%). (b) TCGA TNBC patients with a higher proportion of CD4 memory activated T cells in their tumor sample have a better DFS (p = 0.034, FDR = 0.66, log rank test) (survival rates high vs. low, 5 year: 85.9% and 58.2%, 10 year: 57.3% and 58.2%). (a) and (b) High and low cut offs of T cell infiltrate were chosen as quantities above and below 0.25 times the standard deviation of the mean, respectively. (a) and (b) Images generated with R 4.0.2 (https://www.R-project.org)³⁵.