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. 2021 Feb 25;11:4691. doi: 10.1038/s41598-021-83913-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Top 34 gene mutations in TCGA TNBC cases. (Top left and right) Mutational analysis of the TNBC cases in TCGA identifies TP53 (61.4%), TTN (28.3%), MUC4 (18.9%), MT-CYB (12.6%), SPTA1 (11%), and USH2A (10.2%) as the most frequently mutated genes. (Bottom left) Median and mean mutation count are 77 and 112.1, respectively. (Bottom right) Mutation frequencies of several genes in TNBC as determined by this study (TCGA) or other whole genome or exome sequencing studies (Ref 1 =³⁷, Ref 2 =³⁸). (Top left and right, Bottom left) Images generated with R 4.0.2 (https://www.R-project.org)³⁵. (Bottom right) Image generated with Adobe Photoshop CC 2018 (https://www.adobe.com).