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. 2021 Feb 25;11:4691. doi: 10.1038/s41598-021-83913-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Genes with significantly different mutation frequencies between TCGA TNBC samples with high or low T cells (CD8/CD4 memory activated or CD8). (a, top) 14 genes show significantly different mutation frequencies (p < 0.05, Fisher’s exact test) between the group enriched in both CD8 T cells and CD4 memory activated T cells as compared to the group low in these T cells. (a, bottom) Mutation counts were similar between the two groups. (b, top) 19 genes show significantly different mutation frequencies (p < 0.05, Fisher’s exact test) between the high and low CD8 T cell groups. (b, bottom) Mutation counts were similar between the high and low CD8 T cell groups. (a) and (b) Images generated with R 4.0.2 (https://www.R-project.org)³⁵.