. 2021 Feb 25;11:4691. doi: 10.1038/s41598-021-83913-7

Table 3.

Prognostic value of immune cell types in TCGA TNBC (multivariate).

Model	OS HR (95% CI) pvalue (continuous)	OS HR (95% CI) pvalue (high vs. low) (rows 1-5 and 6-10: 0.25 * sd) (rows 11-13: cluster analysis)	DFS HR (95% CI) pvalue (continuous)	DFS HR (95% CI) pvalue (high vs. low) (rows 1-5 and 6-10: 0.25 * sd) (rows 11-13: cluster analysis)
CD8 T cells	0.000067 (2.2e−08 to 0.20) 0.019	0.19 (0.039–0.87) 0.033	0.067 (7.2e−04 to 6.22) 0.24	0.51 (0.21–1.22) 0.13
Pathologic stage	10.15 (3.51 to 29.35) 1.9e−05	9.25 (2.71–31.61) 0.00039	5.90 (2.73 to 12.77) 6.6e−06	4.95 (1.99–12.36) 0.00060
Age at pathologic diagnosis	0.91 (0.86 to 0.98) 0.0077	0.91 (0.85–0.98) 0.0084	0.95 (0.90 to 1.01) 0.083	0.94 (0.89–1.01) 0.070
Menopause status	2.55 (0.82 to 7.93) 0.11	3.16 (0.88–11.32) 0.077	1.74 (0.61 to 4.97) 0.30	1.77 (0.58–5.37) 0.31
Ethnicity	1.69 (0.50 to 5.71) 0.40	2.16 (0.51–9.20) 0.30	1.66 (0.58 to 4.73) 0.34	2.25 (0.71–7.18) 0.17
CD4 memory activated T cells	0.000047 (3.7e−12 to 579.37) 0.23	0.70 (0.21–2.34) 0.56	0.0000054 (4.27e−12 to 6.88) 0.091	0.61 (0.23–1.61) 0.32
Pathologic stage	5.98 (2.39 to 14.98) 0.00013	7.63 (2.36–24.72) 0.00070	5.21 (2.45 to 11.11) 0.000019	7.49 (2.72–20.65) 0.00010
Age at pathologic diagnosis	0.92 (0.86 to 0.99) 0.017	0.92 (0.85–1.00) 0.050	0.94 (0.89 to 1.00) 0.052	0.94 (0.88–1.00) 0.064
Menopause status	2.46 (0.70 to 8.64) 0.16	1.33 (0.37–4.71) 0.66	2.01 (0.67 to 6.02) 0.21	1.24 (0.41–3.74) 0.71
Ethnicity	2.34 (0.64 to 8.60) 0.20	1.93 (0.45–8.29) 0.38	1.53 (0.54 to 4.32) 0.42	1.31 (0.43–4.02) 0.64
CD8/CD4 (cluster analysis)		0.21 (0.045–0.97) 0.045		0.41 (0.16–1.07) 0.068
Pathologic stage		6.78 (2.31–19.96) 0.00051		4.46 (1.84–10.80) 0.00094
Age at pathologic diagnosis		0.95 (0.90–1.00) 0.053		0.97 (0.92–1.01) 0.14

Model

OS HR (95% CI) pvalue (continuous)

OS HR (95% CI) pvalue (high vs. low) (rows 1-5 and 6-10: 0.25 * sd) (rows 11-13: cluster analysis)

DFS HR (95% CI) pvalue (continuous)

DFS HR (95% CI) pvalue (high vs. low) (rows 1-5 and 6-10: 0.25 * sd) (rows 11-13: cluster analysis)

CD8 T cells

0.000067 (2.2e−08 to 0.20)

0.019

0.19 (0.039–0.87)

0.033

0.067 (7.2e−04 to 6.22)

0.24

0.51 (0.21–1.22)

0.13

Pathologic stage

10.15 (3.51 to 29.35)

1.9e−05

9.25 (2.71–31.61)

0.00039

5.90 (2.73 to 12.77)

6.6e−06

4.95 (1.99–12.36)

0.00060

Age at pathologic diagnosis

0.91 (0.86 to 0.98)

0.0077

0.91 (0.85–0.98)

0.0084

0.95 (0.90 to 1.01)

0.083

0.94 (0.89–1.01)

0.070

Menopause status

2.55 (0.82 to 7.93)

0.11

3.16 (0.88–11.32)

0.077

1.74 (0.61 to 4.97)

0.30

1.77 (0.58–5.37)

0.31

Ethnicity

1.69 (0.50 to 5.71)

0.40

2.16 (0.51–9.20)

0.30

1.66 (0.58 to 4.73)

0.34

2.25 (0.71–7.18)

0.17

CD4 memory activated T cells

0.000047

(3.7e−12 to 579.37)

0.23

0.70 (0.21–2.34)

0.56

0.0000054

(4.27e−12 to 6.88)

0.091

0.61 (0.23–1.61)

0.32

Pathologic stage

5.98 (2.39 to 14.98)

0.00013

7.63 (2.36–24.72)

0.00070

5.21 (2.45 to 11.11)

0.000019

7.49 (2.72–20.65)

0.00010

Age at pathologic diagnosis

0.92 (0.86 to 0.99)

0.017

0.92 (0.85–1.00)

0.050

0.94 (0.89 to 1.00)

0.052

0.94 (0.88–1.00)

0.064

Menopause status

2.46 (0.70 to 8.64)

0.16

1.33 (0.37–4.71)

0.66

2.01 (0.67 to 6.02)

0.21

1.24 (0.41–3.74)

0.71

Ethnicity

2.34 (0.64 to 8.60)

0.20

1.93 (0.45–8.29)

0.38

1.53 (0.54 to 4.32)

0.42

1.31 (0.43–4.02)

0.64

CD8/CD4 (cluster analysis)

0.21 (0.045–0.97)

0.045

0.41 (0.16–1.07)

0.068

Pathologic stage

6.78 (2.31–19.96)

0.00051

4.46 (1.84–10.80)

0.00094

Age at pathologic diagnosis

0.95 (0.90–1.00)

0.053

0.97 (0.92–1.01)

0.14

Bold: pvalue < 0.05.

TCGA: The Cancer Genome Atlas; TNBC: triple negative breast cancer; OS: overall survival; HR: hazard ratio; CI: confidence interval; DFS: disease free survival; sd: standard deviation.