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. 2021 Feb 25;11:4659. doi: 10.1038/s41598-021-84053-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Principal component analysis of WT and mutated spike proteins. (A) eigenvectors of the covariance matrix, (B) percentage of each eigenvector vs eigenvalues, (C) projection of the motion in the phase space along the first and second eigenvectors (PC2 vs. PC1) of the WT, (D) projection of the motion in the phase space along the first and second eigenvectors (PC2 vs. PC1) of the D614G, (E) projection of the motion in the phase space along the first and second eigenvectors (PC2 vs. PC1) of the H49Y, (F) projection of the motion in the phase space along the first and second eigenvectors (PC2 vs. PC1) of T573I. Wild type spike protein is depicted in black, D614G in red, H49Y in green, and T573I in purple.