Table 3.
Mean biochemistry parameters before and after oral (5mg/kg) and intravenous (0.1mg/kg) administration of mitragynine.
| Biochemistry (ref. range) | Orala | Intravenousb | ||
|---|---|---|---|---|
| Pre-dose | Post-dose | Pre-dose | Post-dose | |
| ALP (7–117U/L) | 33.6 ± 9.8 | 38.0 ± 9.9 | 33.6 ± 9.8 | 38.0 ± 9.9 |
| ALB (2.62–3.91 g/dL) | 3.0 ± 0.1 | 3.3 ± 0.2 | 3.1 ± 0.2 | 3.3 ± 0.2 |
| ALT (23–93U/L) | 24.6 ± 2.4 | 27.2 ± 2.4 | 24.6 ± 2.4 | 27.2 ± 2.4 |
| AST (16–53U/L) | 32.6 ± 6.8 | 29.4 ± 4.5 | 32.6 ± 6.8 | 29.4 ± 4.4 |
| Chol (102–340mg/dL) | 179.2 ± 27.7 | 190.8 ± 25.2 | 179.2 ± 27.7 | 190.8 ± 25.2 |
| Glob (1.8–4.0 g/dL) | 2.4 ± 0.1 | 2.54 ± 0.1 | 2.4 ± 0.1 | 2.5 ± 0.1 |
| Glucose (78–124mg/dL) | 71.3 ± 6.4 | 77.3 ± 10.7 | 71.3 ± 6.4 | 82.0 ± 9.9 |
| Magnesium(1.7–2.4mg/dL) | 2.2 ± 0.2 | 2.0 ± 0.1 | 2.2 ± 0.2 | 2.02 ± 0.1 |
| Phosphorus (2.2–4.8mg/dL) | 4.4 ± 0.2 | 4.1 ± 0.6 | 4.4 ± 0.2 | 4.1 ± 0.6 |
| Total Protein (5.0–7.4 g/dL) | 5.5 ± 0.1 | 5.8 ± 0.2 | 5.5 ± 0.1 | 5.8 ± 0.2 |
| Calcium (8.7–10.4mg/dL) | 9.0 ± 0.3 | 8.7 ± 0.3 | 9.0 ± 0.3 | 8.5 ± 0.3 |
| Sodium(141.9–150.6mEq/L) | 146.1 ± 2.1 | 147.7 ± 0.6 | 146.1 ± 2.1 | 147.7 ± 0.6 |
| Potassium(3.8–5.0mEq/L) | 4.9 ± 0.4 | 5.0 ± 0.1 | 4.9 ± 0.4 | 4.9 ± 0.1 |
| T Bilirubin (0.1–0.4mg/dL) | 0.3 ± 0.4 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 |
| Chloride (107.8–117.1mEq/L) | 110.5 ± 4.1 | 109.5 ± 1.8 | 110.5 ± 4.1 | 109.4 ± 1.9 |
| Creatinine (0.6–1.5mg/dL) | 0.9 ± 0.2 | 0.8 ± 0.1 | 0.9 ± 0.2 | 0.8 ± 0.1 |
| BUN (7–27mg/dL) | 25.0 ± 4.5 | 19.2 ± 5.2 | 25.0 ± 4.5 | 19.2 ± 5.2 |
a
N = 5, values are the mean ± SEM;
b
N=4, values are themean ± SEM