Table 4.
Pharmacokinetic parameters of mitragynine after oral (5 mg/kg) and intravenous (0.1 mg/kg) administration in female beagle dogs.
| Parameter | Orala | Intravenousb | |
|---|---|---|---|
| Cmax (ng/mL) | 1 | 278.0 ± 47.4 | – |
| 2 | 236.9 ± 50.2 | – | |
| Tmax (h) | 1 | 0.3 ± 0.1 | – |
| 2 | 1.9 ± 0.7 | – | |
| AUC/Dose (h*kg*ng/mL/mg) | 443.3 ± 33.4 | 637.1 ± 135.4 | |
| Cl (L/h/kg) | – | 1.8 ± 0.4 | |
| Vd (L/kg) | – | 6.3 ± 0.6 | |
| T1/2 (h) | 8.7 ± 0.2 | 2.7 ± 0.6 | |
| Bioavailability (%) | 69.6 | – | |
a
N = 5, values are the mean ± SEM;
b
N = 4, values are the mean ± SEM. Abbreviations: AUC = area under the plasma concentration-time curve, Cl = clearance, Cmax = plasma peak concentration, T1/2 = elimination half-life, Vd = volume of distribution, Tmax = time to reach Cmax