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Pharmacokinetic parameters of 7-hydroxymitragynine after oral (5mg/kg) dose of mitragynine in female beagle dogsa.
| Parameter | 7-Hydroxymitragynine |
|---|---|
| Cmax (ng/mL) | 31.5 ± 3.3 |
| Tmax (h) | 1.7 ± 0.6 |
| %Metabolite ratio (AUC7-hydroxymitragynine/AUCmitragynine)*100 | 12.6 ± 1.6 |
N = 5, values are themean ± SEM. Abbreviations: AUC = area under the plasma concentration-time curve, Cmax = plasma peak concentration, Tmax = time to reach Cmax
