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. 2021 Feb 7;24(3):102166. doi: 10.1016/j.isci.2021.102166

Figure 7.

Figure 7

Prevention of allergic airway inflammation by a Nr4a-ER chimeric molecule

(A) Top: Structures of Nr4a2, estrogen receptor (ER), and the Nr4a2-ER chimeric molecule. DBD: DNA binding domain; LBD: ligand binding domain. Bottom: A schematic of the experiments performed.

(B) Flow cytometry profiles of total CD3+CD4+ cells from spleens of TCRβ−/- mice that received non-Tg or Nr4a2-ER-Tg wild-type (WT) OT-II naive T cells, as indicated.

(C) Quantification of the results in (B).

(D) Eosinophil number and titers of OVA-specific IgE in bronchoalveolar lavage of TCRβ−/- mice that received non-Tg or Nr4a2-ER-Tg WT OT-II naive T cells, as indicated.

(E) PAS staining of lung sections from TCRβ−/- mice that received non-Tg or Nr4a2-ER-Tg WT OT-II naive T cells, as indicated. Scale bars, 100 μm.

Data are representative of two independent experiments, n = 3 each (C and D). Black dots represent individual values. Vertical bars and the error bars indicate mean and SD, respectively (C and D). ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.005, one-way ANOVA with Bonferroni test (C and D).