Table 1.

List of markers of EBI macrophages in mice and human and potential hematopoietic phenotype of gene deletion mice models.

	Mice	Human	Hematopoietic phenotype of gene deletion in mouse
EPOR	+	+	Stat5−/− in macrophages impaired stress erythropoiesis and Epor−/− in macrophages impaired apoptotic cells clearance.
F4/80	+	+	No report
CD11B	+/-	+	No report
CD45	+	+	No report
Ly6C	~69%+	-	No report
Ly6G	-	-	-
VCAM1	+	+	Vcam1−/− in adult BM showed no hematopoietic phenotypes.
EMP	+	+	EMP−/− mice die in utero at E19.5 and EMP−/− in macrophages in adult BM impaired EBI formation.
CD163	~ 35%+	+	No report
CD169	+	+	Deletion of CD169+ macrophages impaired stress erythropoiesis.
αV	+	+	EBIs are markedly decreased in ICAM-4−/−mice in the BM.
ER-HR3	+	+	No report
CD206	~ 15%+	+	No report
TIMD4	+	+	TIMD4 is a phosphatidylserine receptor for the engulfment of apoptotic cells and nucleus.
MERTK	+	+	Axl−/−Mertk−/− mice impaired erythropoiesis in bone marrow and expanded splenic erythropoiesis.
AXL	+	+	Axl−/−Mertk−/− mice impaired erythropoiesis in bone marrow and expanded splenic erythropoiesis.
DNASE2α	+	+	DNASE2α−/− mice die in embryonic E17 because of lethal anemia.
HMOX1	+	+	Hmox1−/−mice exhibits decreased in RBCs size and hemoglobin content.
FPN	+	+	Fpn−/− in macrophages resulted in serum iron deficiency and mild anemia.
TRF	+	+	Hepatocyte-specific Trf knockout mice resulted in iron deficiency anemia.
IGF1	+	+	IGF1 enhances human erythropoiesis.
IL18	+	+	IL18 promotes NK cell proliferation.
VEGFβ	+	+	No report
KLF1	+	+	Klf1−/− die in utero due to severe anemia.
SPIC	+	+	Spic−/− mice exhibit reduced frequencies of pro-E in BM and impaired stress erythropoiesis.
NR1H3	+	+	No report
MAF	+	+	c-Maf−/− mice impaired FL erythropoiesis.

CD, Cluster of differentiation.