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. 2021 Feb 12;11:606759. doi: 10.3389/fphar.2020.606759

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Copyright © 2021 Chao, Cheng, Chang, Huang, Liao, Cheng, Peng and Pao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of physiological and biochemical parameters (A) Mice body weights (B) Variations in food consumption per mouse (C) Random blood glucose (RBS) test (D) Oral glucose tolerance test (OGTT). Seven to eight mice from each group were subjected to the RBS test on the 10th, 11th, 12th, and 15th week. Six mice from each group were subjected to the OGTT on the 16th week. In the OGTT, fasting glucose was conduct at 0 min; subsequently, the mice were orally fed with glucose (2 g/kg), and the blood glucose contents were measured at 30, 60, 90, and 120 min. # significant difference between the diabetic (HFD + STZ) and control (normal) groups (p < 0.05); * significant difference between the treatment (GA 0.2%) and diabetic groups (p < 0.05).