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. 2021 Feb 12;9:607341. doi: 10.3389/fcell.2021.607341

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Copyright © 2021 Zeng, Li, Zou, Chen, Li, Li, Ge, Chen and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of PM2.5 on the area of hEROs and the thickness of hERO-NRs. (A) Bright-field images of hEROs after exposure to four concentrations, group of PM2.5 continuous processing three periods at 1, 2, and 3 weeks. Scale bar = 100 μm. (B) The area of the hEROs in each group was calculated and statistically analyzed. (C) The thickness of the neural retina in each group was calculated and statistically analyzed (control vs. 25 μg/ml vs. 50 μg/ml vs. 100 μg/ml) in PM2.5-treated hEROs after 1, 2, and 3 weeks, respectively. n = 3 independent experiments per group; each group contains 40 hEROs (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).