TABLE 4.

Comparison of single-cell epigenome technologies.

Item	Application	Characteristics	References
scRRBS-seq	DNA methylation	Low throughput, low coverage rate	Guo H. et al., 2015
scBS-seq	DNA methylation	Low throughput, low coverage rate	Smallwood et al., 2014
scCGI-seq	DNA methylation	Low throughput, high coverage rate	Han et al., 2017
scChIL-seq	Histone modification	Low throughput, high coverage rate	Harada et al., 2019
scCUT&tag	Histone modification	High throughput, low coverage rate	Kaya-Okur et al., 2019
scChIC-seq	Histone modification	Low throughput, low coverage rate	Ku et al., 2019
scATAC-seq	Chromatin structure	High throughput, high coverage rate	Buenrostro et al., 2015