Table 2.

Mean SF-36 PF Scale Scores Pre- and Post-Dose 2 by Day and Maximum Reactogenicity Grade (Total Vaccinated Cohort)

Day	Grade 0		Grade 1 or 2		Grade 3
	N	Mean Score	N	Mean Score	N	Mean Score
Baseline	63	78.5	267	82.6	61	82.8
Day −7 pre-dose 1	63	75.6	267	82.0	61	82.6
Day 0 pre-dose 1	63	80.4	267	84.0	61	82.5
Day 60 pre-dose 2	63	79.6	266	81.9	61	83.4
Post-dose 2 (mean)	61	82.5	267	81.9	61	80.4
Day 61	61	83.9	265	78.2	59	68.0
Day 62	61	82.6	265	81.5	59	78.9
Day 63	61	82.4	265	82.5	58	82.2
Day 64	61	82.0	265	82.8	59	82.8
Day 65	61	82.1	265	83.1	59	82.3
Day 66	60	81.8	265	83.2	59	82.6
Day 67a	44	83.2	205	82.9	42	85.5

Notes: N = total number of participants; PF = physical functioning; SF-36 = Short Form Survey-36; high score represents high level of functioning/quality of life (maximum is 100). Baseline is calculated as the mean of Day −7, Day 0 (pre-dose 1), and Day 60 (pre-dose 2).

^aVisit at Day 67: defined as 7-days post-dose 2; not all participants returned for the site visit exactly on Day 67. Reactogenicity grading: 0 (none/normal); 1 (mild); 2 (moderate); 3 (severe; prevents normal activity); for swelling/redness; greatest surface diameter 0 (<20 mm); 1 (≥20 mm–≤50 mm); 2(>50 mm–≤100 mm); 3 (>100 mm); for temperature: 0 (<37.5°C); 1 (37.5°C–38.0°C); 2 (38.1°C–39.0°C); 3 (>39.0°C).