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. 2020 Nov 11;76(3):491–498. doi: 10.1093/gerona/glaa279

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© The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Intervention effects on cognition for different levels of change in relative leucocyte telomere length (LTL). The x-axis shows the annual change in relative LTL. The y-axis shows the FINGER intervention effect (ie, intervention–control difference) on the annual change in cognitive outcomes (standardized z-scores). Positive values indicate cognitive benefit (ie, the intervention effect on cognition favors the intervention group). Error bars are 95% CIs. Average marginal effects are estimated from linear mixed models including randomization group, time, change in LTL, their 2-way interactions, the group × time × change in LTL interaction, age, sex, study site, baseline LTL, and healthy lifestyle change index. An increase in cognitive benefit is seen with an increase in relative LTL (p values are shown for the group × time × change in LTL interaction). (A) Intervention effect on NTB score. (B) Intervention effect on NTB executive functioning. (C) Intervention effect on NTB long-term memory.