Table 2.

FINGER Intervention Effect on Change in LTL—Impact of APOE-ε4 Allele, Age, Sex, and Healthy Lifestyle Changes

	Difference Between Intervention and Control Groups*		Randomization Group × Factor Interaction†
Factor	Unstandardized β-coefficient (95% CI), p value
APOE-ε4 allele	Carriers	0.049 (0.006 to 0.092), p = .025	0.054 (0.007 to 0.102), p = .026
	Noncarriers	−0.006 (−0.033 to 0.021), p = .654
Baseline age	≤69 years	0.035 (0.001 to 0.069), p = .046	−0.005 (−0.010 to −0.001), p = .031
	>69 years	−0.017 (−0.048 to 0.013), p = .258
Healthy lifestyle change index	>Mean	0.022 (−0.010 to 0.055), p = .179	0.047 (0.005 to 0.089), p = .029
	≤Mean	−0.007 (−0.038 to 0.023), p = .643
Sex	Women	−0.004 (−0.038 to 0.031), p = .834	−0.019 (−0.065 to 0.026), p = .40
	Men	0.016 (−0.015 to 0.046), p = .321

Notes: FINGER = Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability; LTL = leukocyte telomere length. Unstandardized β-coefficients (95% CIs) and p values are shown from linear regression models with change in relative LTL as a dependent variable, and randomization group, baseline relative LTL, age, sex, study site, and healthy lifestyle change index as independent variables. Bold font indicates p values less than .05.

*Positive coefficients indicate intervention benefit (intervention–control differences in LTL change favoring the intervention group). For the descriptive purpose, analyses were stratified by factor group: APOE-ε4 carriers and noncarriers; baseline age below and above the rounded mean value; healthy lifestyle change index above and below the mean value (ie, more vs less improvement); and women and men.

†Unstandardized coefficients, 95% CIs, and p values are shown for randomization group × factor interactions where age and healthy lifestyle change index were entered as continuous variables.